Table 3

OR for MRI markers based on the LE8 score and its subscales

Variables	Groups	LE8 score		Medical score		Behavioural score
Variables	Groups	n (%)	Adjusted cOR/OR* (95% CI)	n (%)	Adjusted cOR/OR* (95% CI)	n (%)	Adjusted cOR/OR* (95% CI)
WMH†	Low	108 (23.13)	Ref	221 (24.50)	Ref	85 (15.92)	Ref
	Moderate	357 (17.59)	0.73 (0.57 to 0.95)‡	212 (15.43)	0.60 (0.48 to 0.75)§	249 (17.60)	1.05 (0.78 to 1.41)
	High	45 (7.98)	0.35 (0.24 to 0.51)§	77 (9.81)	0.43 (0.32 to 0.58)§	176 (15.83)	0.91 (0.66 to 1.26)
Modified WMH†	Low	160 (34.26)¶	Ref	330 (36.59)¶	Ref	149 (27.90)¶	Ref
	Low	39 (8.35)**	Ref	76 (8.43)**	Ref	27 (5.06)**	Ref
	Moderate	632 (31.13)¶	0.77 (0.63 to 0.96)‡	397 (28.89)¶	0.64 (0.54 to 0.77)§	449 (31.73)¶	1.10 (0.88 to 1.39)
	Moderate	107 (5.27)**	0.77 (0.63 to 0.96)‡	59 (4.29)**	0.64 (0.54 to 0.77)§	76 (5.37)**	1.10 (0.88 to 1.39)
	High	136 (24.11)¶	0.50 (0.38 to 0.66)§	201 (25.61)¶	0.58 (0.47 to 0.72)§	330 (29.68)¶	0.92 (0.72 to 1.19)
	High	5 (0.89)**	0.50 (0.38 to 0.66)§	16 (2.04)**	0.58 (0.47 to 0.72)§	48 (4.32)**	0.92 (0.72 to 1.19)
Lacunes	Low	53 (11.35)	Ref	81 (8.98)	Ref	44 (8.24)	Ref
	Moderate	105 (5.17)	0.49 (0.34 to 0.70)§	68 (4.95)	0.56 (0.40 to 0.79)§	85 (6.01)	0.75 (0.50 to 1.12)
	High	12 (2.13)	0.24 (0.13 to 0.47)§	21 (2.68)	0.34 (0.21 to 0.57)§	41 (3.69)	0.47 (0.29 to 0.77)‡
CMBs††	Low	60 (12.85)	Ref	107 (11.86)	Ref	66 (12.36)	Ref
	Moderate	216 (10.64)	0.91 (0.67 to 1.25)	140 (10.19)	0.89 (0.68 to 1.17)	144 (10.18)	0.88 (0.63 to 1.22)
	High	37 (6.56)	0.62 (0.40 to 0.97)‡	66 (8.41)	0.80 (0.57 to 1.11)	103 (9.26)	0.84 (0.58 to 1.21)
Modified CMBs††	Low	47 (10.06)¶	Ref	89 (9.87)¶	Ref	58 (10.86)¶	Ref
	Low	13 (2.78)**	Ref	18 (2.0)**	Ref	8 (1.50)**	Ref
	Moderate	195 (9.61)¶	0.89 (0.66 to 1.22)	125 (9.1)¶	0.88 (0.67 to 1.16)	125 (8.83)¶	0.88 (0.64 to 1.23)
	Moderate	21 (1.03)**	0.89 (0.66 to 1.22)	15 (1.09)**	0.88 (0.67 to 1.16)	19 (1.34)**	0.88 (0.64 to 1.23)
	High	34 (6.03)¶	0.61 (0.39 to 0.95)	62 (7.90)¶	0.79 (0.56 to 1.10)	93 (8.36)¶	0.84 (0.58 to 1.20)
	High	3 (0.53)**	0.61 (0.39 to 0.95)	4 (0.51)**	0.79 (0.56 to 1.10)	10 (0.90)**	0.84 (0.58 to 1.20)
BG-EPVS‡‡	Low	71 (15.20)	Ref	116 (12.86)	Ref	67 (12.55)	Ref
	Moderate	201 (9.90)	0.70 (0.52 to 0.96)‡	134 (9.75)	0.79 (0.59 to 1.04)‡	154 (10.88)	0.88 (0.63 to 1.24)
	High	28 (4.96)	0.42 (0.26 to 0.68)§	50 (6.37)	0.60 (0.41 to 0.87)‡	79 (7.10)	0.57 (0.38 to 0.84)‡
Modified BG-EPVS‡‡	Low	10 (2.14)	Ref	12 (1.33)	Ref	7 (1.31)	Ref
	Moderate	26 (1.28)	0.81 (0.38 to 1.75)	20 (1.46)	1.21 (0.57 to 2.55)	25 (1.77)	1.83 (0.76 to 4.41)
	High	2 (0.35)	0.31 (0.07 to 1.44)	6 (0.76)	0.75 (0.27 to 2.09)	6 (0.54)	0.65 (0.21 to 2.03)

LE8 score, medical score or behavioural score was categorised as low (0–60), moderate (60–80) or high (80–100) risk.
*Model 2: Adjusted for age, sex, eGFR, previous antiplatelet, anticoagulants drugs use. Modified WMH and modified CMBs were analyzed by ordinal logistic models and presented as cOR.
†WMH was defined as either (early) confluent deep WMH (Fazekas score 2 or 3) or irregular periventricular WMH extending into the deep white matter (Fazekas score 3); Modified WMH was classified into grade 0: total periventricular + subcortical WMH grade 1-2, grade 1: total periventricular + subcortical WMH grade 3-4 and grade 2: total periventricular + subcortical WMH grade 5-6.
‡P value < 0.05
§P value < 0.001
¶Grade 1: Modified WMH or modified CMBs.
**Grade 2: Modified WMH or modified CMBs.
††CMBs was defined as presence of any microbleeds; Modified CMBs was classified as grade 0: absent, grade 1: 1-4 microbleeds and grade 2: ≥5 microbleeds.
‡‡Moderate to severe (>10) perivascular space in basal ganglia was considered BG-EPVS; Frequent to severe (>20) perivascular space in basal ganglia was considered Modified BG-EPVS.
BG-EPVS, enlarged perivascular space in basal ganglia; CMBs, cerebral microbleeds; cOR, common OR; eGFR, estimated glomerular filtration rate; LE8, Life’s Essential 8; WMH, white matter hyperintensities.