Comparison of in-hospital outcomes in patients aged>80 years for stroke with or without alteplase treatment
| Outcome variable | Outcome rates (%) | Odds ratio (95% CI) | |||
| With alteplase | Without alteplase | Unadjusted | IPTW* | PSM† | |
| Primary outcome | |||||
| mRS 0–2 at discharge | 4815 (55.5) | 13 789 (62.0) | 0.80 (0.76 to 0.84) | 1.12 (1.06 to 1.18) | 1.25 (1.16 to 1.34) |
| Secondary outcomes | |||||
| mRS 0–1 at discharge | 3743 (43.3) | 10 828 (48.7) | 0.76 (0.73 to 0.80) | 1.14 (1.08 to 1.19) | 1.26 (1.17 to 1.35) |
| Independent ambulation at discharge | 5640 (65.0) | 15 935 (71.7) | 0.73 (0.70 to 0.77) | 1.14 (1.08 to 1.20) | 1.22 (1.13 to 1.31) |
| Safety outcomes | |||||
| sICH‡ | 423 (4.9) | 273 (1.2) | 4.12 (3.53 to 4.81) | 3.22 (2.77 to 3.75) | 3.21 (2.64 to 3.90) |
| In-hospital mortality | 203 (2.3) | 292 (1.3) | 1.80 (1.50 to 2.16) | 1.12 (0.93 to 1.35)§ | 1.22 (0.99 to 1.50)¶ |
*Model adjusted for sex, age, body mass index, prior stroke or transient ischaemic attack, atrial fibrillation, NIHSS Score at admission, onset-to-door time, antiplatelet agents, statins, insurance and hospital characteristics by IPTW.
†Model adjusted potential residual confounders (NIHSS Score at admission and pre-stroke mRS 0–2) after PSM.
‡According to the National Institute of Neurological Disorders and Stroke criterion.
§P=0.23.
¶P=0.06.
IPTW, inverse probability-weighted score; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; PSM, Propensity score matching; sICH, symptomatic intracranial haemorrhage.