Primary and secondary outcomes in different stenosis locations
| Categories | ICA (n=126) | Incidence difference (95% CI) | HR (95% CI) | P value | MCA (n=341) | Incidence difference (95% CI) | HR (95% CI) | P value | VA (n=140) | Incidence difference (95% CI) | HR (95% CI) | P value | BA (n=202) | Incidence difference (95% CI) | HR(95% CI) | P value | ||||
| PTAS group (n=60) | Medical group (n=66) | PTAS group (n=157) | Medical group (n=184) | PTAS group (n=84) | Medical group (n=56) | PTAS group (n=99) | Medical group (n=103) | |||||||||||||
| Components of the primary outcome | 16 (26.67%) | 11 (16.67%) | 10.00 (−4.50 to 24.49) | 1.68 (0.78 to 3.62) | 0.19 | 13 (8.28%) | 18 (9.78%) | −1.50 (−7.66 to 4.66) | 0.85 (0.42 to 1.74) | 0.66 | 8 (9.52%) | 6 (10.71%) | −1.19 (−11.50 to 9.12) | 0.91 (0.32 to 2.62) | 0.86 | 17 (17.17%) | 8 (7.77%) | 9.40 (0.31 to 2.04) | 2.38 (1.03 to 5.52) | 0.04 |
| Stroke or death within 30 days after enrolment | 9 (15.00%) | 6 (9.09%) | 8 (5.10%) | 7 (3.80) | 6 (7.14%) | 1 (1.79%) | 13 (13.13%) | 3 (2.91%) | ||||||||||||
| Stroke in territory of qualifying artery beyond 30 days through 1 year | 7 (11.67%) | 5 (7.58%) | 5 (3.18%) | 11 (5.98) | 2 (2.38%) | 5 (8.93%) | 4 (4.04%) | 5 (4.85%) | ||||||||||||
| Secondary outcomes | ||||||||||||||||||||
| Stroke in the same territory within 2 years | 17 (28.33%) | 11 (16.67%) | 11.67 (−2.98 to 26.32) | 1.78 (0.83 to 3.84) | 0.14 | 12 (7.64%) | 21 (11.41%) | −3.77 (−10.09 to 2.55) | 0.70 (0.34 to 1.44) | 0.33 | 9 (10.71%) | 6 (10.71%) | 0.00 (-10.63 to 10.63) | 1.07 (0.35 to 3.26) | 0.91 | 17 (17.17%) | 8 (7.77%) | 9.40 (0.31 to 18.50) | 2.39 (1.03 to 5.55) | 0.04 |
| Stroke in the same territory within 3 years | 17 (28.33%) | 12 (18.18%) | 10.15 (−4.72 to 25.02) | 1.64 (0.77 to 3.46) | 0.20 | 15 (9.55%) | 22 (11.96%) | −2.40 (−9.06 to 4.26) | 0.84 (0.43 to 1.62) | 0.60 | 10 (11.90%) | 6 (10.71%) | 1.19 (−9.74 to 12.12) | 1.20 (0.40 to 3.58) | 0.75 | 18 (18.18%) | 8 (7.77%) | 10.41 (1.19 to 19.64) | 2.54 (1.10 to 5.84) | 0.03 |
| Disabling stroke or death within 3 years | 13 (21.67%) | 9 (13.64%) | 8.03 (5.41 to 21.47) | 1.65 (0.71 to 3.87) | 0.25 | 6 (3.82%) | 14 (7.61%) | −3.79 (−8.81 to 1.23) | 0.50 (0.19 to 1.30) | 0.15 | 9 (10.71%) | 4 (7.14%) | 3.70 (−6.31 to 13.71) | 1.55 (0.48 to 5.03) | 0.47 | 12 (12.12%) | 5 (4.85%) | 7.27 (−0.41 to 14.94) | 2.66 (0.94 to 7.55) | 0.07 |
| Death within 3 years | 6 (10.33%) | 3 (4.55%) | 5.46 (−3.66 to 14.57) | 2.27 (0.57 to 9.06) | 0.25 | 5 (3.18%) | 5 (2.72%) | 0.47 (−3.15 to 4.08) | 1.19 (0.34 to 4.09) | 0.79 | 6 (7.14%) | 2 (3.57%) | 3.57 (−4.38 to 11.52) | 2.06 (0.42 to 10.23) | 0.38 | 1 (1.01%) | 3 (2.91%) | −1.90 (−5.78 to 1.97) | 0.34 (0.04 to 3.30) | 0.36 |
| Any stroke within 3 years | 18 (30.00%) | 14 (21.21%) | 8.79 (−6.62 to 24.2) | 1.49 (0.74 to 2.99) | 0.27 | 17 (10.83%) | 22 (11.96%) | −1.13 (−7.95 to 5.69) | 0.90 (0.48 to 1.69) | 0.73 | 8 (9.52%) | 6 (10.71%) | −1.19 (−11.50 to 9.12) | 0.90 (0.31 to 2.59) | 0.84 | 19 (19.19%) | 10 (9.71%) | 9.48 (−0.21 to 19.17) | 2.14 (0.99 to 4.60) | 0.05 |
| Myocardial infarction within 3 years | 4 (6.67%) | 4 (6.06%) | 0.61 (−8.07 to 9.28) | 1.11 (0.28 to 4.43) | 0.89 | 1 (0.64%) | 4 (2.17%) | −1.54 (−4.11 to 1.03) | 0.29 (0.03 to 2.61) | 0.27 | 3 (3.57%) | 1 (1.79%) | 1.79 (−3.93 to 7.50) | 0.49 (0.05 to 4.76) | 0.54 | 3 (3.03%) | 4 (3.88%) | −0.85 (−5.95 to 4.25) | 0.78 (0.17 to 3.49) | 0.75 |
Data are n (%), or median (IQR).
Boldface values indicate statistically significant differences
BA, basilar artery; ICA, internal carotid artery; MCA, middle cerebral artery; PTAS, percutaneous transluminal angioplasty and stenting; VA, vertebral artery.