Participant distribution and WMH volume change (mL) after applying the four approaches to one dataset
| Approach | N (%) regression | Regressing WMH change (mL) | N (%) stable | Stable WMH change (mL) | N (%) progression | Progressing WMH change (mL) |
| Threshold 1 | ||||||
| Mean volume (SD), (range) | 59 (29.8) | −1.36 (1.42) (−7.98 to –0.26) | 110 (55.6) | 0.86 (0.89) (−0.23, 2.81) | 29 (14.6) | 6.22 (3.07) (2.88, 12.84) |
| Threshold 2 | ||||||
| Mean volume (SD), (range) | 59 (29.8) | −1.36 (1.42) (−7.98 to –0.26) | 33 (16.7) | −0.02 (0.14) (−0.23, 0.22) | 106 (53.5) | 2.59 (2.82) (0.25, 12.84) |
| Percentile | ||||||
| Mean volume (SD), (range) | 56 (28.3) | −1.42 (1.43) (−7.98 to –0.33) | 42 (21.2) | −0.01 (0.18) (−0.28, 0.30) | 100 (50.5) | 2.73 (2.85) (0.32, 12.84) |
| Quintile | Q1 (N=40) | Q2 (N=40) | Q3 (N=40) | Q4 (N=39) | Q5 (N=39) | |
| Mean (SD), (range) | −1.79 (1.54) (−7.98 to –0.68) | −0.27 (0.20) (−0.65, 0.03) | 0.35 (0.18) (0.04, 0.70) | 1.43 (0.48) (0.75, 2.33) | 5.31 (3.07) (2.43, 12.84) | |
Q, quintile; WMH, white matter hyperintensity.