Overview of the four existing approaches to define WMH change
| Approach | Regression | Stable | Progression |
| Threshold 112 | Decrease>0.25 mL | Volumes from −0.25 mL up to 1 SD (of mean WMH volume change) | Increase >1 SD (of mean WMH volume change) |
| Threshold 23 | Decrease>0.25 mL | Volumes from −0.25 mL up to +0.25 mL | Increase >0.25 mL |
| Percentile4 | Percentiles below the −10th percentile of no change | Percentile of no volume change ±10 percentiles | Percentiles above the +10th percentile of no change |
| Quintile7 | Data are divided in quintiles reflecting any net volume change. Quintile 1 (Q1): most volume decrease; quintile 5 (Q5): most volume increase | ||
WMH, white matter hyperintensity.