Comparison of demographic, clinical and radiological characteristics between patients with space-occupying cerebellar infarct with and without malignant swelling
| Total cohort (n=93) | Malignant swelling (n=33) | No malignant swelling (n=60) | OR | 95% CI for OR | P value* | Adjusted P value† | |
| Demographic characteristics | |||||||
| Age (years), mean (±SD) | 67.8 (±12.2) | 67.6 (±12.6) | 67.9 (±12.1) | 0.998 | (0.964 to 1.033) | 0.911 | >0.999 |
| Female, n (%) | 33 (35.5 %) | 12 (36.4 %) | 21 (35.0%) | 1.061 | (0.438 to 2.573) | 0.895 | >0.999 |
| Acute stroke severity index | |||||||
| NIHSS on admission, median (range) | 5 (0–38) | 12 (1–38) | 4 (0–36) | 1.078 | (1.034 to 1.124) | <0.001 | 0.008 |
| Cause of infarction according to TOAST criteria, n (%) | |||||||
| Large-artery atherosclerosis | 17 (18.3%) | 7 (21.2%) | 10 (16.7%) | 1.346 | (0.459 to 3.948) | 0.588 | >0.999 |
| Cardioembolism | 35 (37.6%) | 14 (42.4%) | 21 (35.0%) | 1.368 | (0.573 to 3.268) | 0.480 | >0.999 |
| Small-vessel occlusion | 0 | 0 | 0 | ||||
| Stroke of other determined aetiology | 12 (12.9%) | 2 (9.1%) | 10 (16.7%) | 0.567 | (0.142 to 2.258) | 0.421 | >0.999 |
| Stroke of undetermined aetiology | 29 (31.2%) | 9 (27.3%) | 20 (33.3%) | 0.750 | (0.294 to 1.911) | 0.547 | >0.999 |
| Imaging | |||||||
| Infarct volume (cm3), mean (±SD) | 48.4 (±16.1) | 61.8 (±17.1) | 41.0 (±9.5) | 1.136 | (1.078 to 1.196) | <0.001 | <0.001 |
| Infarct volume ≥38 cm3, n (%) | 62 (66.7%) | 32 (97.0%) | 30 (50.0%) | 32.000 | (4.104 to 249.489) | <0.001 | <0.001 |
| Brainstem compression in baseline CT or MRI, n (%) | 9 (9.7%) | 5 (15.2%) | 4 (6.7%) | 2.500 | (0.622 to 10.046) | 0.197 | >0.999 |
| Vascular territory, n (%) | |||||||
| PICA | 60 (64.5%) | 19 (57.6%) | 41 (68.3%) | 0.629 | (0.261 to 1.515) | 0.301 | >0.999 |
| SCA | 11 (11.8%) | 1 (3.0%) | 10 (16.7%) | 0.156 | (0.019 to 1.280) | 0.084 | >0.999 |
| AICA | 0 | 0 | 0 | ||||
| Multiple different territories | 22 (23.7%) | 13 (39.4%) | 9 (15.0%) | 3.683 | (1.362 to 9.961) | 0.010 | 0.170 |
| Side of the cerebellum | 0.085 | >0.999 | |||||
| Bilateral | 24 (25.8%) | 12 (36.4%) | 12 (20.0%) | 3.333 | (1.117 to 9.946) | 0.031 | 0.496 |
| Left | 30 (32.3%) | 12 (36.4%) | 18 (30.0%) | 2.222 | (0.783 to 6.308) | 0.134 | >0.999 |
| Right | 39 (41.9%) | 9 (27.3%) | 30 (50.0%) | 1 | |||
| Brainstem infarction | 27 (29.0%) | 17 (51.5%) | 10 (16.7%) | 5.312 | (2.028 to 13.914) | <0.001 | 0.013 |
| Basilar artery occlusion | 26 (28.0%) | 13 (39.4%) | 13 (21.7%) | 2.350 | (0.927 to 5.956) | 0.072 | >0.999 |
| Therapy, n (%) | |||||||
| Intravenous tPA | 16 (17.2%) | 7 (21.2%) | 9 (15.0%) | 1.526 | (0.510 to 4.560) | 0.450 | >0.999 |
| EVT | 24 (25.8%) | 11 (33.3%) | 13 (21.7%) | 1.808 | (0.700 to 4.671) | 0.222 | >0.999 |
| Failed revascularisation (TICI 0 to 2 a) | 5 (5.4%) | 5 (15.2%) | 0 | 23.361 | (0.949 to 575.075) | 0.054‡ | 0.810‡ |
*P value of the Wald statistic from the corresponding univariate logistic regression model with dependent variable malignant swelling (yes/no).
†P value of the Wald statistic from the corresponding univariate logistic regression model with dependent variable malignant swelling (yes/no), adjusted for multiple testing.
‡Logistic regression with Firth correction due to one category with frequency of zero.
AICA, Anterior inferior cerebellar artery; EVT, endovascular treatment; NIHSS, National Institutes of Health Stroke Scale; PICA, Posterior inferior cerebellar artery; SCA, Superior cerebellar artery; TOAST, Trial of Org 10172 in Acute Stroke Treatment; tPA, tissue plasminogen activator .