Baseline characteristics of participants in the MRI substudy
| Standard medical care (n=139) | MISTIE (n=149) | EOT volume ≤15 mL (n=94) | |
| Sex, number (%) | |||
| Male | 85 (61) | 89 (60) | 56 (60) |
| Female | 56 (39) | 60 (40) | 38 (40) |
| Age, median (IQR), years | 62 (52–71) | 62 (52–68) | 63 (52–69) |
| Hypertension, number (%) | 137 (99) | 143 (96) | 92 (98) |
| Diabetes, number (%) | 45 (32) | 45 (30) | 27 (29) |
| Coronary artery disease, number (%) | 17 (12) | 23 (17) | 13 (14) |
| Anticoagulant use, number (%) | 4 (3) | 15 (10) | 4 (4) |
| Antiplatelet use, number (%) | 52 (37) | 44 (30) | 28 (30) |
| Current smoker, number (%) | 19 (14) | 37 (25) | 25 (27) |
| Alcohol abuse, number (%) | 12 (9) | 26 (17) | 13 (14) |
| Baseline CT and clinical factors | |||
| Diagnostic ICH volume, median (IQR), mL | 40.5 (30.8–54.9) | 42.2 (30.7–51.3) | 36.8 (29.3–49.6) |
| Diagnostic IVH volume, median (IQR), mL | 0 (0–1.8) | 0 (0–1.6) | 0 (0–1.1) |
| IVH present at diagnosis, number (%) | 57 (41) | 57 (38) | 32 (34) |
| Lobar haematoma, number (%) | 58 (42) | 54 (36) | 30 (32) |
| GCS at randomisation, median (IQR) | 10 (8–13) | 10 (8–13) | 10 (8–13) |
| Systolic blood pressure, median (IQR), mm Hg | 180 (160–202) | 181 (155–208) | 180 (149–213) |
| Diastolic blood pressure, median (IQR), mm Hg | 98 (84–119) | 98 (84–115) | 98 (84–115) |
| Mean arterial pressure at first 24 hours, median (IQR) | 92 (83–98) | 92 (86–97) | 93 (86–98) |
| Surgical group, number (%) | 0 | 149 (100) | 91 (97) |
| EOT CT ICH volume ≤15 mL, number (%) | 3 (2) | 91 (61) | 94 (100) |
EOT, end-of-treatment; GCS, glasgow coma scale; ICH, intracerebral haemorrhage; INR, international normalised ratio; IVH, intraventricular haemorrhage; MISTIE, minimally invasive surgery plus alteplase for intracerebral haemorrhage evacuation; PTT, partial thromboplastin time.