Table 1

The results of MR analysis, sensitivity analysis and Steiger directionality test

Exposure	Tissue	Outcome	Method	Nsnp	Pval	OR	Lci95	Uci95	Q_pval	Pleiotropy_pval	correct_causal_direction	steiger_pval
PSMA4	Blood	SAH	IVW	2	7.52e-08	2.00	1.53	2.50	0.44	NA	TRUE	0.02
PRCP	Blood	SAH	IVW	7	1.20e-08	0.59	0.49	0.70	0.64	0.23	TRUE	0.001
LTBP4	Blood	SAH	IVW	6	2.45e-06	0.48	0.35	0.65	0.39	0.16	TRUE	0.31
GPR160	Blood	SAH	IVW	3	7.57e-08	0.83	0.77	0.90	0.37	0.74	TRUE	1.01e-54
KL	Blood	UIA	IVW	12	3.89e-06	0.51	0.39	0.68	0.29	0.02	TRUE	0.005
PSMA4	Blood	IA	IVW	2	3.57e-09	1.90	1.54	2.35	0.66	NA	TRUE	0.02
SLC22A4	Blood	IA	IVW	6	3.70e-09	1.41	1.26	1.58	0.51	0.20	TRUE	2.55e-12

IA, intracranial aneurysm; Lci, lower CI; MR, Mendelian randomisation; SAH, subarachnoid haemorrhage (the rupture of intracranial aneurysms); Uci, upper CI; UIA, unruptured of intracranial aneurysm.