Baseline characteristics and demographics in patients who had successful reperfusion
| mRS 0–2 n=494 | mRS 3–6 n=414 | P value | sICH* n=56 | Non-sICH n=847 | P value | |
| Age, median (IQR), year | 67 (57–74) | 72 (64–78) | <0.001 | 69 (60–77) | 69 (60–76) | 0.983 |
| Male, n (%) | 316 (64) | 227 (54.8) | 0.005 | 36 (64.3) | 503 (59.4) | 0.469 |
| Hypertension | 303 (61.3) | 288 (69.6) | 0.010 | 34 (60.7) | 554 (65.4) | 0.475 |
| Diabetes mellitus | 66 (13.4) | 93 (22.5) | <0.001 | 12 (21.4) | 147 (17.4) | 0.438 |
| Clinical characteristics, median (IQR) | ||||||
| Baseline NIHSS scores | 13 (11–17) | 16 (13–20) | <0.001 | 16 (13–19) | 14 (12–18) | 0.010 |
| Baseline ASPECT scores | 9 (8–10) | 8 (6–9) | <0.001 | 8 (7–9) | 9 (8–10) | 0.008 |
| IVT, n (%) | 91 (18.4) | 67 (16.2) | 0.376 | 14 (25) | 144 (17) | 0.127 |
| Blood pressure parameters, median (IQR) | ||||||
| Baseline SBP, mm Hg | 150 (131–164) | 154 (139–170) | <0.001 | 149 (130–160) | 150 (135–168) | 0.140 |
| Baseline DBP, mm Hg | 83 (74–92) | 84 (75–95) | 0.392 | 84 (74–92) | 83 (74–93) | 0.562 |
| Mean SBP (24 hours), mm Hg | 121 (115–128) | 123 (117–130) | 0.001 | 126 (116–133) | 122 (116–129) | 0.073 |
| Mean DBP (24 hours), mm Hg | 70 (65–75) | 69 (63–75) | 0.181 | 69 (65–78) | 70 (64–75) | 0.440 |
| SBPr, % | 17.5 (8.6–25.7) | 19.2 (10.9–28.1) | 0.029 | 14.5 (2.7–20.8) | 18.3 (9.9–26.7) | 0.013 |
| DBPr, % | 16 (6.2–24.2) | 17.8 (7.8–27.1) | 0.059 | 13.2 (3.9–25.1) | 17.1 (7.1–26) | 0.132 |
| Continuous intravenous antihypertensive agents, n (%) | 246 (49.8) | 260 (62.8) | <0.001 | 37 (66.1) | 466 (55) | 0.107 |
| TOAST classification, n (%) | <0.001 | 0.473 | ||||
| LAA | 164 (33.2) | 106 (25.6) | 13 (23.2) | 257 (30.3) | ||
| Cardioembolic | 256 (51.8) | 278 (67.1) | 37 (66.1) | 492 (58.1) | ||
| Others | 74 (15) | 30 (7.2) | 6 (10.7) | 98 (11.6) | ||
| Occlusion site, n (%) | <0.001 | 0.786 | ||||
| ICA | 162 (32.8) | 189 (45.7) | 24 (42.9) | 324 (38.3) | ||
| MCA M1 | 281 (56.9) | 193 (46.6) | 27 (48.2) | 445 (52.5) | ||
| MeVO | 51 (10.3) | 32 (7.7) | 5 (8.9) | 78 (9.2) | ||
| OTP, mean (IQR), min | 300 (225–370) | 300 (220–390) | 0.486 | 300 (221–360) | 300 (225–390) | 0.849 |
| OTR, mean (IQR), min | 349 (278–438) | 352 (288–470) | 0.087 | 360 (288–440) | 350 (282–455) | 0.695 |
| Collateral score†, n (%) | <0.001 | 0.008 | ||||
| Poor | 158 (32.1) | 255 (61.7) | 35 (62.5) | 373 (44.2) | ||
| Good | 334 (67.9) | 158 (38.3) | 21 (37.5) | 471 (55.8) | ||
*5 patients missing.
†3 patients missing.
ASPECT, Alberta Stroke Programme Early CT; DBP, diastolic blood pressure; DBPr, DBP reduction; ICA, internal carotid artery; IVT, intravenous thrombolysis; LAA, large-artery atherosclerosis; MCA, middle cerebral artery; MeVO, medium vessel occlusions; NIHSS, National Institutes of Health Stroke Scale; OTP, symptoms onset to groin puncture time; OTR, symptoms onset to reperfusion; SBP, systolic blood pressure; SBPr, SBP reduction; sICH, symptomatic intracranial haemorrhage; TOAST, the Trial of ORG 10172 in Acute Stroke Treatment.