Association between anaesthetic techniques and outcomes of interest: general anaesthesia versus non-general anaesthesia
| N | Unadjusted | Adjusted model 1* | PSM | Missing, n | ||
| General anaesthesia | Non-general anaesthesia | Effect size (95% CI)† | Effect size (95% CI)† | Effect size (95% CI)† | ||
| 84 | 146 | 230 | 230 | 130 | ||
| Primary outcome | ||||||
| mRS of 0–2 at the 90-day follow-up | 23 (27.4) | 46 (31.5) | 0.82 (0.45 to 1.48) | 0.97 (0.51 to –1.86) | 0.86 (0.40 to –1.84) | 0 |
| Secondary outcomes | ||||||
| mRS score at the 90-day follow-up | 4 (2-6) | 3.5 (2-5) | 0.75 (0.47 to 1.20) | 0.83 (0.51 to 1.35) | 0.70 (0.38 to –1.28) | 0 |
| mRS of 0–3 at the 90-day follow-up | 36 (42.9) | 73 (50.0) | 0.75 (0.44 to 1.29) | 0.88 (0.48 to 1.60) | 0.73 (0.37 to –1.46) | 0 |
| 36-hour ΔNIHSS | 0 (-5–3.5) | 1 (-1–4) | −2.78 (-5.11 to –0.45) | −2.68 (-5.03 to –0.33) | −2.42 (–5.68 to 0.85) | 0 |
| Change from baseline in infarct volume | 65.1 (29.0–143.4) | 57.3 (30.8–128.7) | 2.85 (−24.15 to 29.86) | 1.28 (−26.06 to 28.62) | 15.25 (−19.71 to 50.21) | 3 |
| Successful reperfusion (mTICI 2b-3) | 69 (82.1) | 114 (80.3) | 1.13 (0.56 to 2.26) | 1.11 (0.54 to 2.27) | 0.90 (0.37 to 2.22) | 4 |
| Safety outcomes | ||||||
| Pneumonia | 26 (31.0) | 25 (17.1) | 2.17 (1.15 to 4.08) | 2.03 (1.04 to 3.98) | 2.42 (1.08 to 5.42) | 0 |
| sICH within 48 hours | 6 (7.1) | 8 (5.5) | 1.33 (0.44 to 3.96) | 1.18 (0.37 to 3.77) | 1.27 (0.33 to 4.96) | 0 |
| Any ICH within 48 hours | 41 (48.8) | 72 (49.3) | 0.98 (0.57 to 1.68) | 0.94 (0.54 to 1.65) | 1.21 (0.60 to 2.41) | 0 |
| Death within 90-day | 22 (26.2) | 27 (18.5) | 1.56 (0.82 to 2.97) | 1.50 (0.75 to 2.97) | 2.38 (0.98 to 5.80) | 0 |
| Decompressive hemicraniectomy during hospitalisation | 8 (9.5) | 9 (6.2) | 1.60 (0.59 to 4.32) | 1.51 (0.53 to 4.36) | 4.42 (0.90 to 21.69) | 0 |
| Any procedural complications‡ | 7 (8.3) | 10 (6.8) | 1.19 (0.44 to 3.26) | 1.32 (0.47 to 3.71) | 1.25 (0.32 to 4.88) | 5 |
*Adjusted for age, prestroke mRS score, baseline NIHSS score, baseline ASPECTS, core infarct volume, time from onset to puncture and receipt of intravenous thrombolysis in the intention-to-treat population.
†The results of the binary logistic regression are reported as ORs with 95% CIs, those of the linear regression are reported as β values with 95% CIs and those of the ordinal logistic regression are reported as cORs with 95% CIs.
‡Procedural complications include arterial dissection, arterial perforation, vasospasm requiring treatment and embolisation in a new territory.
ASPECTS, Alberta Stroke Programme Early CT Score; cOR, crude OR; ICH, intracranial haemorrhage; mRS, modified Rankin scale; mTICI, modified thrombolysis in cerebral infarction; NIHSS, National Institutes of Health Stroke Scale; PSM, propensity score matching; sICH, symptomatic ICH.