Published data on baseline characteristics and outcomes in patients who had AIS-despite-OAC and kept on OAC without left atrial appendage closure
| Author, year | Study design | No. of pts. | Age (years) | CHA2DS2-VASc | HAS-BLED | Follow-up | Recurrent AIS risk | Recurrent ICH risk |
| Seiffge et al9 2020 | Pooled analysis from prospective, observational registries | 1195 | 79 (73–84) | 5 (4–6) | 3 (3–4) | 318 days | 8.9 per 100 patient-years | 2.0 per 100 patient-years |
| Benz et al15 2023 | Individual participant data from five randomised trials | 1163 | 73 (67–78) | 4 (3–6) | N/A | 337 days | 7 per 100 patient-years | N/A |
| Tanaka et al16 2020 | Pooled analysis from prospective, observational registries | 1129 | 75 (70–80) | N/A | N/A | 1 year | 5.3 per 100 patient-years | 0.6 per 100 patient-years |
| Pacciaroni et al18 2022 | Prospective, observational | 1240 | 78.9±9.1 | 77.1%≥4 | 38.1%≥3 | 15 months | 7.2 per 100 patient-years | 1.5 per 100 patient-years |
AIS, acute ischaemic stroke; ICH, intracerebral haemorrhage; N/A, not available; OAC, oral anticoagulant.