Table 1

Baseline characteristics of the participants

Characteristics	Tenecteplase (n=76)	Alteplase (n=61)	P value
Age (IQR), years	82.0 (81.0–86.0)	83.0 (81.0–85.0)	0.86
Sex, n (%)			0.66
Male	32 (42.1)	28 (45.9)
Female	44 (57.9)	33 (54.1)
Weight (IQR), kg	55.0 (47.0–65.0)	57.0 (50.0–65.0)	0.63
Medical history, n (%)
Hypertension	56 (73.7)	44 (72.1)	0.84
Diabetes	13 (17.1)	15 (24.6)	0.28
Dyslipidaemia	8 (10.5)	15 (24.6)	0.03
Coronary heart disease	26 (34.2)	22 (36.1)	0.82
Current smoking, n (%)	8 (10.5)	8 (13.1)	0.51
History of medication use, n (%)
Antiplatelet agents	10 (13.2)	9 (14.8)	0.79
Anticoagulant agents	0 (0.0)	1 (1.6)	0.45
Lipid-lowering drugs	8 (10.5)	7 (11.5)	0.86
Hypoglycaemic drugs	4 (5.3)	6 (9.8)	0.49
Antihypertensive drugs	29 (38.2)	27 (44.3)	0.47
mRS score before stroke, n (%)			0.77
0	66 (86.8)	54 (88.5)
1	10 (13.2)	7 (11.5)
Baseline NIHSS score (IQR)	9 (6–14)	9 (6–12)	0.87
Baseline NIHSS score categories, n (%)			0.66
≤7	31 (40.8)	22 (36.1)
8–14	29 (38.2)	28 (45.9)
≥15	16 (21.1)	11 (18.0)
Onset-to-needle time (IQR), min	174.0 (138.5–207.0)	184.0 (146.0–230.0)	0.14
Onset-to-needle time categories, n (%)			0.26
<3 hours	41 (54.0)	27 (44.3)
≥3 hours	35 (46.1)	34 (55.7)
Door-to-needle time (IQR), min	64.0 (50.0–82.0)	65.0 (50.0–90.0)	0.84
Bridging thrombectomy, n (%)	3 (4.0)	2 (3.3)	>0.99
Total costs (IQR), yuan	9725.76 (7382.68–13 552.70)	12 701.15 (7819.84–19 371.11)	0.11
Thrombolysis costs (IQR), yuan	3688.00 (3688.00–7376.00)	5340.24 (3570.00–5340.24)	0.01
Hospital stay, n (%)			0.10
≤7 days	14 (20.0)	19 (32.8)
>7 days	56 (80.0)	39 (67.2)
Data missing	6	3