Table 1

Timing of all procedures in Head dOwn-Position for acutE moderate ischaemic Stroke with large artery atherosclerosis(HOPES 3)

Timepoint	Screening	0	48±12 hours	10±2 days	90±7 days
Eligibility screen	x
Informed consent	x
Randomisation	x
Head CT/MRI	x*		x
NIHSS assessment	x		x	x
Prestroke mRS assessment	x				x
Medical history	x
Population characteristics	x
Vital signs	x		x	x	x
TOAST classification				x
Blood routine	x
Coagulation	x
Serum biochemistry	x
ECG	x
24-hour ECG monitor				x†
Concomitant medication			x	x	x
Adverse events			x	x	x
Recurrent stroke and other vascular events			x	x	x

*MRI including diffusion-weighted imaging is required either at baseline or at 48 hours.
†Performed within 10 days after admission.
mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; TOAST, Trial of Org 10 172 in Acute Stroke Treatment.