Baseline characteristics of patients grouped by onset to treatment times
| Onset to treatment times 0–90 min (N=84) | Onset to treatment times 91–180 min (N=622) | Onset to treatment times 181–270 min (N=706) | P value | |
| Mean age—year | 62.4±10.4 | 65.1±11.5 | 65.6±11.2 | 0.02 |
| Age group—year | 0.05 | |||
| 18–59 | 34 (40.5) | 196 (31.5) | 197 (27.9) | |
| 60–79 | 47 (56.0) | 361 (58.0) | 440 (62.3) | |
| ≥80 | 3 (3.6) | 65 (10.5) | 69 (9.8) | |
| Male sex—no (%) | 59 (70.2) | 420 (67.5) | 488 (69.1) | 0.77 |
| Weight (IQR)—kg | 68 (60–77) | 67 (60–75) | 65 (58–75) | 0.12 |
| Medical history—no (%) | ||||
| Hypertension | 63 (75.0) | 438 (70.4) | 517 (73.2) | 0.43 |
| Diabetes mellitus | 23 (27.4) | 166 (26.7) | 188 (26.6) | 0.99 |
| Hyperlipidaemia | 17 (20.2) | 138 (22.2) | 132 (18.7) | 0.29 |
| Coronary heart disease | 17 (20.2) | 156 (25.1) | 158 (22.4) | 0.40 |
| Arrhythmia | 10 (11.9) | 139 (22.3) | 132 (18.7) | 0.04 |
| Current smoking—no (%) | 35 (41.7) | 228 (36.7) | 276 (39.1) | 0.50 |
| History of medication use—no (%) | ||||
| Antiplatelet agents | 10 (11.9) | 82 (13.2) | 90 (12.7) | 0.94 |
| Anticoagulant agents | 1 (1.2) | 2 (0.3) | 9 (1.3) | 0.16 |
| Antihypertensive drugs | 41 (48.8) | 256 (41.2) | 317 (44.9) | 0.23 |
| Hypoglycaemic drugs | 11 (13.1) | 109 (17.5) | 104 (14.7) | 0.29 |
| Lipid-lowering drugs | 10 (11.9) | 53 (8.5) | 64 (9.1) | 0.59 |
| Pre-stroke mRS—no (%) | 0.19 | |||
| 0 | 76 (90.5) | 566 (91.0) | 621 (88.0) | |
| 1 | 8 (9.5) | 56 (9.0) | 85 (12.0) | |
| NIHSS score* | ||||
| Median (IQR) | 8 (6–11) | 7 (6–10) | 7 (6–10) | 0.02 |
| Mild (≤7) | 37 (44.0) | 340 (54.7) | 427 (60.5) | 0.003 |
| Moderate (8–14) | 43 (51.2) | 225 (36.2) | 218 (30.9) | |
| Severe (≥15) | 4 (4.8) | 57 (9.2) | 61 (8.6) | |
| Onset-to-needle time (IQR)—min | 75 (65–84) | 140 (117–84) | 226 (204–248) | <0.001 |
| Door-to-needle time—min | 46 (39–56) | 58 (47–74) | 65 (48–90) | <0.001 |
| Bridging thrombectomy | 7 (8.3) | 24 (3.9) | 19 (2.7) | 0.03 |
*NIHSS scores range from 0 to 42, with higher scores indicating more severe stroke.
mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale.