Table 4

Association of the RNF213 p.R4810K variant with clinical outcomes

Outcomes	Events (number of events/total patients, %)			OR/HR (95% CI)	P value	Adjusted OR/HR (95% CI)*	Adjusted P value*
Outcomes	All patients	Carriers	Non-carriers	OR/HR (95% CI)	P value	Adjusted OR/HR (95% CI)*	Adjusted P value*
3 months
Stroke	653/10381 (6.3)	4/56 (7.1)	649/10325 (6.3)	1.13 (0.42 to 3.01)	0.81	1.19 (0.44 to 3.17)	0.74
Ischaemic stroke	609/10381 (5.9)	4/56 (7.1)	605/10325 (5.9)	1.21 (0.45 to 3.24)	0.70	1.27 (0.48 to 3.41)	0.63
CVD†	677/10381 (6.5)	4/56 (7.1)	673/10325 (6.5)	1.09 (0.41 to 2.91)	0.86	1.15 (0.43 to 3.08)	0.77
Mortality	157/10381 (1.5)	0/56 (0)	157/10325 (1.5)	–	0.97	–	0.97
mRS 3~6	1392/10262 (13.6)	6/55 (10.9)	1386/10207 (13.6)	0.78 (0.33 to 1.82)	0.57	0.91 (0.39 to 2.14)	0.83
1 year
Stroke	1029/10381 (9.9)	7/56 (12.5)	1022/10325 (9.9)	1.27 (0.60 to 2.66)	0.53	1.34 (0.64 to 2.81)	0.45
Ischaemic stroke	940/10381 (9.1)	7/56 (12.5)	933/10325 (9.0)	1.39 (0.66 to 2.93)	0.38	1.47 (0.70 to 3.10)	0.31
CVD†	1087/10381 (10.5)	7/56 (12.5)	1080/10325 (10.5)	1.20 (0.57 to 2.52)	0.63	1.27 (0.60 to 2.67)	0.53
Mortality	349/10381 (3.4)	0/56 (0)	349/10325 (3.4)	–	0.95	–	0.95
mRS 3~6	1346/10130 (13.3)	2/55 (3.6)	1346/10075 (13.3)	0.25 (0.06 to 1.01)	0.05	0.30 (0.07 to 1.25)	0.10

*Adjusted model: adjusted by age, sex, BMI, smoking status and medical history (hypertension, diabetes mellitus and dyslipidaemia).
†CVD included ischaemic stroke, haemorrhagic stroke, myocardial infarction and vascular death.
BMI, body mass index; CVD, composite vascular events; mRS, modified Rankin Scale.