Table 1

MMP-12 levels increase in the brain after cerebral ischaemia followed by reperfusion

SpeciesStroke induction methodResults (related to MMP-12 expression)Reference
MousePermanent CAO and 50 min hypoxiaMMP-12 expressed in microglia and neurons on day 1 post-CAO.
Increased MMP-12 mRNA and protein expression on day 3.		Svedin et al, Developmental Neuroscience 200940
Rat2 hour MCAOIncreased MMP-12 mRNA and protein expression on post-ischaemic days 1, 3, 5, 7 and 14.
MMP-12 expressed in neurons, oligodendrocytes and microglia/macrophages on day 7.		Chelluboina et al, Scientific Reports 201535
Rat2 hour MCAOIncreased MMP-12 expression immediately after ischaemia (1 hour, 2 hours and 4 hours MCAO); increase more pronounced on day 1.Chelluboina et al, Stroke 201536
Mouse1 hour MCAOIncreased MMP-12 mRNA expression on post-ischaemic day 1.Nalamolu et al, Stroke and Vascular Neurology 201841
MousePhotothrombotic cortical ischaemiaIncreased MMP-12 mRNA expression on post-ischaemic day 3.
MMP-12 expressed in microglia.		Hohjoh et al, Neuroscience Letters 202042
Mouse1 hour MCAOIncreased protein expression of MMP-12 on post-ischaemic day 1.Arruri et al, Neurochemistry International 202237
Rat2 hour MCAOIncreased mRNA expression of MMP-12 on post-ischaemic days 1, 3, and 7.
MMP-12 expression not elevated in contralateral hemisphere.		Challa et al, Frontiers in Neuroscience 202239

  • CAO, carotid artery occlusion; MCAO, middle cerebral artery occlusion.