Table 1

The intervention of ticagrelor related stroke trials

Trails	Intervention	Control	Duration
THALES	Ticagrelor 180 mg loading dose followed by 90 mg two times per day plus aspirin	Aspirin	30 days
PRINCE	Ticagrelor 180 mg loading dose followed by 90 mg two times per day plus aspirin	Clopidogrel 300 mg loading dose followed by 75 mg daily plus aspirin	21 days
CHANCE 2	Ticagrelor 180 mg loading dose followed by 90 mg two times per day plus aspirin	Clopidogrel 300 mg loading dose followed by 75 mg daily plus aspirin	21 days
SOCRATES	Ticagrelor 180 mg loading dose followed by 90 mg two times per day	Aspirin	90 days

CHANCE 2, Ticagrelor or Clopidogrel with Aspirin in High-Risk Patients with Acute Nondisabling Cerebrovascular Events II; PRINCE, Platelet Reactivity in Acute Stroke or Transient Ischaemic Attack; SOCRATES, Stroke or Transient Ischaemic Attack Treated with Aspirin or Ticagrelor and Patient Outcomes; THALES, Ticagrelor and ASA for Prevention of Stroke and Death.