Table 1

List of studies with sex-specific outcomes

Study	Female/male	Interventions	Per cent stenosis	Outcome(s) assessed
ECST11	850/2168	CEA/BMT	0%–99%	Model of stroke-free life expectancy stratified by age and per cent stenosis
NASCET12	873/2012	CEA/BMT	>70%; 50%–69%;<50%	5-year risk of ipsilateral stroke stratified by per cent stenosis
SPACE13 14	338/858	CEA/CAS	>50%	30-day risk of death of any cause, ipsilateral stroke or haemorrhage 30-day risk of stroke and death and 2-year risk of ipsilateral ischaemic stroke (combined)
EVA-3S15	130/397	CEA/CAS	>60%	30-day risk of death, any stroke and 4-year risk of ipsilateral stroke (combined)
CAVATAS16	152/352	CEA/CAS	>60%	8-year risk of any stroke or perioperative death (combined)
ICSS17	503/1207	CEA/CAS	>50%	120-day risk of stroke, death or myocardial infarction (combined)
CREST3 18	872/1630	CEA/CAS	>50% >60%	30-day risk of myocardial infarction, stroke or death 4-year risk of myocardial infarction, stroke or death 30-day (myocardial infarction, stroke or death) and 10-year risk of ipsilateral stroke (combined)
Pooled individual patient data meta-analysis
NASCET and ESCT4 5	1718/4175	CEA/BMT	>50%	5-year relative risk of ipsilateral ischaemic stroke or death, stratified by time from last symptomatic event to randomisation 5-year risk of stroke and death in surgery patients, stratified by per cent stenosis and time from last symptomatic event to randomisation 5-year risk of ipsilateral ischaemic stroke and any stroke or death within 30 days of randomisation (combined) 5-year risk of ipsilateral ischaemic stroke and any stroke or death within 30 days of randomisation (combined), stratified by per cent stenosis
EVA-3S, SPACE, ICSS, CREST trials9	1437/3317	CEA/CAS	Multiple thresholds	120-day risk of any stroke or death and 5-year risk of ipsilateral stroke (combined) 5-year risk of ipsilateral stroke
EVA-3S, SPACE, BACASS, ICSS, CREST trials10	1466/3395	CEA/CAS	Multiple thresholds	30-day risk of death or any stroke (combined)

BACASS, Basel Carotid Artery Stenting Study; BMT, best medical therapy; CAS, carotid artery stenting; CAVATAS, Carotid And Vertebral Artery Transluminal Angioplasty Study; CEA, carotid endarterectomy; CREST, Carotid Revascularisation Endarterectomy Versus Stenting Trial; ECST, European Carotid Surgery Trial; EVA-3S, Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis; ICSS, International Carotid Stenting Study; NASCET, North American Symptomatic Carotid Endarterectomy Trial; SPACE, Stent-Supported Percutaneous Angioplasty of the Carotid Artery Versus Endarterectomy.