Association between depressive symptoms and risk of diabetes, stroke, heart disease and subsequent all-cause mortality
| Transitions | N (events) | Unadjusted | Model 1 | Model 2 | Model 3 |
| A (healthy to diabetes) | 4742/78 212 | 1.30 (1.22 to 1.38) | 1.36 (1.27 to 1.45) | 1.16 (1.09 to 1.24) | 1.12 (1.05 to 1.20) |
| B (healthy to stroke) | 2173/78 212 | 1.37 (1.25 to 1.50) | 1.41 (1.28 to 1.55) | 1.34 (1.21 to 1.48) | 1.31 (1.18 to 1.44) |
| C (healthy to heart disease) | 5487/78 212 | 1.35 (1.27 to 1.43) | 1.40 (1.32 to 1.48) | 1.28 (1.20 to 1.36) | 1.26 (1.18 to 1.34) |
| D (healthy to mortality) | 7182/78 212 | 1.68 (1.60 to 1.77) | 1.70 (1.62 to 1.79) | 1.52 (1.44 to 1.60) | 1.41 (1.34 to 1.49) |
| E (diabetes to mortality) | 458/4742 | 1.64 (1.35 to 1.98) | 1.68 (1.38 to 2.05) | 1.60 (1.30 to 1.97) | 1.54 (1.25 to 1.89) |
| F (stroke to mortality) | 410/2173 | 1.43 (1.17 to 1.75) | 1.55 (1.26 to 1.91) | 1.43 (1.15 to 1.78) | 1.29 (1.03 to 1.61) |
| G (heart disease to mortality) | 707/5487 | 1.21 (1.04 to 1.42) | 1.32 (1.12 to 1.56) | 1.23 (1.04 to 1.46) | 1.21 (1.02 to 1.44) |
Data are presented as HR and 95% CI. Model 1 adjusted for age and gender. Model 2 adjusted for model 1 plus educational status, marital status, taking medication for depression or anxiety, number of disease and country. Model 3 adjusted for model 2 plus obesity, drinking, smoking and physical activity.