RT Journal Article SR Electronic T1 Thrombolysis for ischaemic stroke despite direct oral anticoagulation JF Stroke and Vascular Neurology JO Stroke Vasc Neurol FD BMJ Publishing Group Ltd SP 464 OP 466 DO 10.1136/svn-2023-002727 VO 9 IS 5 A1 Purrucker, Jan C. A1 Meinel, Thomas R. A1 Wilson, Duncan A1 Xian, Ying A1 Wu, Teddy Y. A1 Seiffge, David J. YR 2024 UL http://svn.bmj.com/content/9/5/464.abstract AB Intravenous thrombolysis is not recommended in anticoagulated patients receiving direct oral anticoagulants (DOACs) and a recent intake within the last 48 hours in US and European guidelines. However, three observational studies now suggest safety of thrombolysis in patients with recent intake of DOACs, and thus support previous experimental data. In this perspective, the current evidence and practical consequences are discussed.