RT Journal Article
SR Electronic
T1 Central post-stroke pain: advances in clinical and preclinical research
JF Stroke and Vascular Neurology
JO Stroke Vasc Neurol
FD BMJ Publishing Group Ltd
SP svn-2024-003418
DO 10.1136/svn-2024-003418
A1 Yuan, Xiqian
A1 Hu, Siyuan
A1 Fan, Xiaochong
A1 Jiang, Chao
A1 Xu, Yan
A1 Hao, Ruochen
A1 Xu, Zili
A1 Yu, Yiyang
A1 Rastegar-Kashkooli, Yousef
A1 Huang, Leo
A1 Wang, Tom J
A1 Wang, Qiao
A1 Su, Songxue
A1 Wang, Limin
A1 Wang, Junyang
A1 Wang, Menglu
A1 Kim, Yun Tai
A1 Bhawal, Ujjal K
A1 Wang, Fushun
A1 Zhao, Ting
A1 Wang, Junmin
A1 Chen, Xuemei
A1 Wang, Jian
YR 2024
UL http://svn.bmj.com/content/early/2024/09/27/svn-2024-003418.abstract
AB Central poststroke pain (CPSP) is a medical complication that arises poststroke and significantly impacts the quality of life and social functioning of affected individuals. Despite ongoing research, the exact pathomechanisms of CPSP remain unclear, and practical treatments are still unavailable. Our review aims to systematically analyse current clinical and preclinical studies on CPSP, which is critical for identifying gaps in knowledge and guiding the development of effective therapies. The review will clarify the clinical characteristics, evaluation scales and contemporary therapeutic approaches for CPSP based on clinical investigations. It will particularly emphasise the CPSP model initiated by stroke, shedding light on its underlying mechanisms and evaluating treatments validated in preclinical studies. Furthermore, the review will not only highlight methodological limitations in animal trials but also offer specific recommendations to researchers to improve the quality of future investigations and guide the development of effective therapies. This review is expected to provide valuable insights into the current knowledge regarding CPSP and can serve as a guide for future research and clinical practice. The review will contribute to the scientific understanding of CPSP and help develop effective clinical interventions.