RT Journal Article
SR Electronic
T1 Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese
JF Stroke and Vascular Neurology
JO Stroke Vasc Neurol
FD BMJ Publishing Group Ltd
SP 399
OP 406
DO 10.1136/svn-2023-002428
VO 9
IS 4
A1 Yang, Songchun
A1 Sun, Zhijia
A1 Sun, Dong
A1 Yu, Canqing
A1 Guo, Yu
A1 Sun, Dianjianyi
A1 Pang, Yuanjie
A1 Pei, Pei
A1 Yang, Ling
A1 Millwood, Iona Y
A1 Walters, Robin G
A1 Chen, Yiping
A1 Du, Huaidong
A1 Lu, Yan
A1 Burgess, Sushila
A1 Avery, Daniel
A1 Clarke, Robert
A1 Chen, Junshi
A1 Chen, Zhengming
A1 Li, Liming
A1 Lv, Jun
A1 
YR 2024
UL http://svn.bmj.com/content/9/4/399.abstract
AB Background and purpose Previous studies, mostly focusing on the European population, have reported polygenic risk scores (PRSs) might achieve risk stratification of stroke. We aimed to examine the association strengths of PRSs with risks of stroke and its subtypes in the Chinese population.Methods Participants with genome-wide genotypic data in China Kadoorie Biobank were split into a potential training set (n=22 191) and a population-based testing set (n=72 150). Four previously developed PRSs were included, and new PRSs for stroke and its subtypes were developed. The PRSs showing the strongest association with risks of stroke or its subtypes in the training set were further evaluated in the testing set. Cox proportional hazards regression models were used to estimate the association strengths of different PRSs with risks of stroke and its subtypes (ischaemic stroke (IS), intracerebral haemorrhage (ICH) and subarachnoid haemorrhage (SAH)).Results In the testing set, during 872 919 person-years of follow-up, 8514 incident stroke events were documented. The PRSs of any stroke (AS) and IS were both positively associated with risks of AS, IS and ICH (p<0.05). The HR for per SD increment (HRSD) of PRSAS was 1.10 (95% CI 1.07 to 1.12), 1.10 (95% CI 1.07 to 1.12) and 1.13 (95% CI 1.07 to 1.20) for AS, IS and ICH, respectively. The corresponding HRSD of PRSIS was 1.08 (95% CI 1.06 to 1.11), 1.08 (95% CI 1.06 to 1.11) and 1.09 (95% CI 1.03 to 1.15). PRSICH was positively associated with the risk of ICH (HRSD=1.07, 95% CI 1.01 to 1.14). PRSSAH was not associated with risks of stroke and its subtypes. The addition of current PRSs offered little to no improvement in stroke risk prediction and risk stratification.Conclusions In this Chinese population, the association strengths of current PRSs with risks of stroke and its subtypes were moderate, suggesting a limited value for improving risk prediction over traditional risk factors in the context of current genome-wide association study under-representing the East Asian population.Data are available on reasonable request. Details of how to access China Kadoorie Biobank data and details of the data release schedule are available from www.ckbiobank.org/site/Data+Access.