RT Journal Article
SR Electronic
T1 White matter disease derived from vascular and demyelinating origins
JF Stroke and Vascular Neurology
JO Stroke Vasc Neurol
FD BMJ Publishing Group Ltd
SP 344
OP 350
DO 10.1136/svn-2023-002791
VO 9
IS 4
A1 Zhang, Lin-Jie
A1 Tian, De-Cai
A1 Yang, Li
A1 Shi, Kaibin
A1 Liu, Yaou
A1 Wang, Yilong
A1 Shi, Fu-Dong
YR 2024
UL http://svn.bmj.com/content/9/4/344.abstract
AB Damage or microstructural alterations of the white matter can cause dysfunction of the intrinsic neural networks in a condition termed as white matter disease (WMD). Frequently detected on brain computed tomography and magnetic resonance imaging scans, WMD is commonly presented in inflammatory demyelinating diseases like multiple sclerosis (MS) and vascular diseases such as cerebral small vessel disease (CSVD). Prevention of MS and CSVD progression requires early treatments with drastically different medications and approaches, as such, early and accurate diagnosis of WMD, derived from vascular or demyelinating etiologies, is of paramount importance. However, the clinical and imaging similarities between MS, especially during the early stage, and CSVD, pose a significant dilemma in differentiating these two conditions. In this review, we attempt to summarize and contrast the distinguishing features of MS and CSVD for aiding accurate diagnosis to ensure timely corresponding management in the early stages of MS and CSVD.