RT Journal Article
SR Electronic
T1 Association between Life’s Essential 8 and Cerebral Small Vessel Disease
JF Stroke and Vascular Neurology
JO Stroke Vasc Neurol
FD BMJ Publishing Group Ltd
SP svn-2023-002628
DO 10.1136/svn-2023-002628
A1 Liu, Dandan
A1 Cai, Xueli
A1 Yang, Yingying
A1 Wang, Suying
A1 Mei, Lerong
A1 Jing, Jing
A1 Li, Shan
A1 Wang, Mengxing
A1 Chen, Yun
A1 Meng, Xia
A1 Wei, Tiemin
A1 Wang, Yongjun
A1 Wang, Yilong
A1 Pan, Yuesong
YR 2023
UL http://svn.bmj.com/content/early/2023/11/20/svn-2023-002628.abstract
AB Background Given that associations of Life’s Essential 8 (LE8) and cerebral small vessel disease (CSVD) or its imaging markers were unclear, we examined relationship between them.Methods The cross-sectional study included community residents from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events study. We calculated the total LE8 score, medical LE8 score and behavioural score, and categorised them into low (<60), moderate (60–79) or high (≥80) group. MRI markers included lacunes, white matter hyperintensities (WMH), enlarged perivascular spaces in basal ganglia (BG-EPVS) and cerebral microbleeds (CMB). In respect of, total CSVD score (0–4 points), WMH, lacunes or CMB were categorised as two grades, and BG-EPVS (N>10) was allocated one point. Based on modified total CSVD score (0–6 points), WMH or CMB was modified to three grades, and BG-EPVS (N>20) was allocated one point.Results Among 3061 participants in this study, 1424 (46.5%) were male. Higher LE8 score was associated with lower total CSVD score (moderate vs low: cOR 0.78, 95% CI 0.63 to 0.96; high vs low: cOR 0.44, 95% CI 0.33 to 0.59), and the medical score was inversely related to the total CSVD score. Furthermore, the medical score was inversely related to odds of WMH (p<0.05), modified WMH (p<0.05), lacunes (p<0.05) or BG-EPVS (p<0.05), and the behavioural score were inversely related to the odds of lacunes and BG-EPVS.Conclusions Higher LE8 score which indicates better cardiovascular status was associated with lower burden of CSVD and its MRI markers. Longitudinal studies are needed to examine the causality.Data are available on reasonable request. The data are available to researchers on reasonable request from the corresponding author.