RT Journal Article
SR Electronic
T1 Differential associations of lipoprotein(a) level with cerebral large artery and small vessel diseases
JF Stroke and Vascular Neurology
JO Stroke Vasc Neurol
FD BMJ Publishing Group Ltd
SP svn-2022-001625
DO 10.1136/svn-2022-001625
A1 Pan, Yuesong
A1 Cai, Xueli
A1 Jing, Jing
A1 Wang, Suying
A1 Meng, Xia
A1 Mei, Lerong
A1 Yang, Yingying
A1 Jin, Aoming
A1 DongXiao, Yao
A1 Li, Shan
A1 Li, Hao
A1 Wei, Tiemin
A1 Wang, Yongjun
A1 Wang, Yilong
YR 2022
UL http://svn.bmj.com/content/early/2022/07/18/svn-2022-001625.abstract
AB Background and purpose Cerebral large artery and small vessel diseases are related to different pathogenetic mechanisms and have different risk factor profile. Lipoprotein(a) (Lp(a)) was shown to promote atherosclerosis but data was limited on its association with cerebral small vessel diseases (cSVD). The objective of this study was to assess the associations of Lp(a) level with the two types of cerebrovascular diseases.Methods Community-dwelling subjects aged 50–75 years from the baseline survey of The PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events study were included. Lp(a) concentrations was measured and categorised into three groups according to the tertiles. Eligible participants were scanned by a 3.0T MRI scanner and assessed for intracranial atherosclerosis and cSVD burden based on four imaging markers.Results This study included 3059 subjects. The average age of the participants was 61.2±6.7 years, and 53.5% (1636) were female. Compared with the first tertile, subjects with the second and third tertiles of Lp(a) concentrations were associated with an increased odds of presence of intracranial plaque (18.7% vs 15.4%, adj.OR 1.37, 95% CI 1.08 to 1.75; 18.9% vs 15.4%, adj.OR 1.34, 95% CI 1.05 to 1.72). Similar associations were observed for intracranial atherosclerotic burden. Whereas, subjects with the third tertile of Lp(a) level had a decreased odds of presence of cSVD (25.9% vs 31.7%, adj.OR 0.74, 95% CI 0.60 to 0.92) and lower cSVD burden (adj.cOR 0.76, 95% CI 0.62 to 0.94).Conclusions In this study, Lp(a) concentrations were positively associated with presence and burden of intracranial atherosclerosis, but was inversely associated with cSVD.Trial registration number NCT03178448.Data are available on reasonable request. Data related to the analysis are available to researchers on request to reproduce the results or replicate the procedure by directly contacting the corresponding author.