RT Journal Article
SR Electronic
T1 Associations between haemodynamics and wall enhancement of intracranial aneurysm
JF Stroke and Vascular Neurology
JO Stroke Vasc Neurol
FD BMJ Publishing Group Ltd
SP svn-2020-000636
DO 10.1136/svn-2020-000636
A1 Zhang, Miaoqi
A1 Peng, Fei
A1 Tong, Xin
A1 Feng, Xin
A1 Li, Yunduo
A1 Chen, Huijun
A1 Niu, Hao
A1 Zhang, Baorui
A1 Song, Guangrong
A1 Li, Youxiang
A1 Liu, Peng
A1 Liu, Aihua
A1 Li, Rui
YR 2021
UL http://svn.bmj.com/content/early/2021/02/25/svn-2020-000636.abstract
AB Background and purpose Previous studies have reported about inflammation processes (IPs) that play important roles in aneurysm formation and rupture, which could be driven by blood flow. IPs can be identified using aneurysmal wall enhancement (AWE) on high-resolution black-blood MRI (BB-MRI) and blood flow haemodynamics can be demonstrated by four-dimensional-flow MRI (4D-flow MRI). Thus, this study investigated the associations between AWE and haemodynamics in unruptured intracranial aneurysms (IA) by combining 4D-flow MRI and high-resolution BB-MRI.Materials and methods Between April 2014 and October 2017, 48 patients with 49 unruptured IA who underwent both 4D-flow MRI and high-resolution BB-MRI were retrospectively included in this study. The haemodynamic parameters demonstrated using 4D-flow MRI were compared between different AWE patterns using the Kruskal-Wallis test and ordinal regression.Results The results of Kruskal-Wallis test showed that the average wall shear stress in the IA (WSSavg-IA), maximum through-plane velocity in the adjacent parent artery, inflow jet patterns and the average vorticity in IA (vorticityavg-IA) were significantly associated with the AWE patterns. Ordinal regression analysis identified WSSavg-IA (p=0.002) and vorticityavg-IA (p=0.033) as independent predictors of AWE patterns.Conclusion A low WSS and low average vorticity were independently associated with a high AWE grade for IAs larger than 4 mm. Therefore, WSS and average vorticity could predict AWE and circumferential AWE.