RT Journal Article SR Electronic T1 Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management JF Stroke and Vascular Neurology JO Stroke Vasc Neurol FD BMJ Publishing Group Ltd SP 177 OP 179 DO 10.1136/svn-2020-000398 VO 5 IS 2 A1 Zhou, Yifan A1 Li, Wei A1 Wang, David A1 Mao, Ling A1 Jin, Huijuan A1 Li, Yanan A1 Hong, Candong A1 Chen, Shengcai A1 Chang, Jiang A1 He, Quanwei A1 Wang, Mengdie A1 Hu, Bo YR 2020 UL http://svn.bmj.com/content/5/2/177.abstract AB Coronavirus disease-2019 (COVID‐19) has become a global pandemic. COVID-19 runs its course in two phases, the initial incubation phase and later clinical symptomatic phase. Patients in the initial incubation phase often have insidious clinical symptoms, but they are still highly contagious. At the later clinical symptomatic phase, the immune system is fully activated and the disease may enter the severe infection stage in this phase. Although many patients are known for their respiratory symptoms, they had neurological symptoms in their first 1–2 days of clinical symptomatic phase, and ischaemic stroke occurred 2 weeks after the onset of the clinical symptomatic phase. The key is to prevent a patient from progressing to this severe infection from mild infection. We are sharing our experience on prevention and management of COVID-19.