RT Journal Article
SR Electronic
T1 Role of the glymphatic system in ageing and diabetes mellitus impaired cognitive function
JF Stroke and Vascular Neurology
FD BMJ Publishing Group Ltd
SP 90
OP 92
DO 10.1136/svn-2018-000203
VO 4
IS 2
A1 Zhang, Li
A1 Chopp, Michael
A1 Jiang, Quan
A1 Zhang, Zhenggang
YR 2019
UL http://svn.bmj.com/content/4/2/90.abstract
AB Diabetes mellitus (DM) is a common metabolic disease in the middle-aged and older population, and is associated with cognitive impairment and an increased risk of developing dementia. The glymphatic system is a recently characterised brain-wide cerebrospinal fluid and interstitial fluid drainage pathway that enables the clearance of interstitial metabolic waste from the brain parenchyma. Emerging data suggest that DM and ageing impair the glymphatic system, leading to accumulation of metabolic wastes including amyloid-β within the brain parenchyma, and consequently provoking cognitive dysfunction. In this review, we concisely discuss recent findings regarding the role of the glymphatic system in DM and ageing associated cognitive impairment.