RT Journal Article
SR Electronic
T1 Targeting NAMPT as a therapeutic strategy against stroke
JF Stroke and Vascular Neurology
JO Stroke Vasc Neurol Stroke Vasc Neurol
FD BMJ Publishing Group Ltd
SP svn-2018-000199
DO 10.1136/svn-2018-000199
A1 Wang, Shu-Na
A1 Miao, Chao-Yu
YR 2019
UL http://svn.bmj.com/content/early/2019/04/04/svn-2018-000199.abstract
AB Stroke is the second and the leading most common cause of death in the world and China, respectively, but with few effective therapies. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme for nicotinamide adenine dinucleotide (NAD) salvage synthesis in mammals, thereby influencing NAD-dependent enzymes and constituting a strong endogenous defence system against various stresses. Accumulating in-vitro and in-vivo studies have demonstrated the neuroprotective effect of NAMPT in stroke. Here, we review the direct evidence of NAMPT as a promising target against stroke from five potential therapeutic strategies, including NAMPT overexpression, recombinant NAMPT, NAMPT activators, NAMPT enzymatic product nicotinamide mononucleotide (NMN), and NMN precursors nicotinamide riboside and nicotinamide, and describe the relevant mechanisms and limitations, providing a promising choice for developing novel and effective therapeutic interventions against ischaemic and haemorrhagic stroke.