RT Journal Article
SR Electronic
T1 Effect of ischaemic brain injury on sexual function in adult mice
JF Stroke and Vascular Neurology
FD BMJ Publishing Group Ltd
SP 127
OP 132
DO 10.1136/svn-2016-000013
VO 1
IS 3
A1 Tang, Yaohui
A1 Yuan, Falei
A1 Cai, Beibei
A1 Xia, Weiliang
A1 Wang, Yongting
A1 Yang, Guo-Yuan
YR 2016
UL http://svn.bmj.com/content/1/3/127.abstract
AB Objective Priapism refers to a condition with persistent abnormal erection of the penis, which is usually caused by disease or injury in the brain or spinal cord, or obstruction to the outflow of blood through the dorsal vein at the root of the penis, without sexual desires. The effect of cerebral ischaemia on sexual function is unknown. The aim of this study is to explore whether priapism occurs in adult mice. Furthermore, we examined the relationship between priapism and the region of infarct in the brain.Design Adult male CD-1 mice who underwent permanent middle cerebral artery occlusion (pMCAO) were closely examined from 2 hours to 14 days postoperation.Results We found that priapism occurs in ∼80% of the mice with pMCAO, which could persist up to 14 days. Further study has demonstrated that the occurrence of priapism is related to the infarct region: priapism is found only in mice with ischaemic injury extending to the hypothalamus and the hippocampus regions.Conclusion Our result suggested priapism may be used as a deep brain injury marker for evaluating brain injury in mice after pMCAO.